The paper focuses on the history of the first three Bible women, Mary Wesley, Martha Reuben, and Bathsheba, who came from marginalised communities in Rayalaseema, and emerged as new leaders of social change in the context of colonial modernity and Christianity in the region. The emergence of a modern profession of Bible woman for Dalit women in the 1870s was transformative, opening doors of education, learning, and transforming them into local leaders. Bible women played a pivotal role in the history of Dalits, gender, and missions by shaping the life and community of Dalits and spreading Christianity in Rayalaseema.