The Lady Tata Memorial Trust, established in 1932 in Bombay, was among the earliest philanthropic foundations created to support leukaemia research globally. Very little was known about leukaemia, a major mystery in medical science, at the time. The trust provided fellowships and grants to some of the leading international researchers and contributed signifi cantly to the advancement of knowledge about leukaemia. This article presents an account of its work during the first two decades and throws light on a little known aspect in the history of international and Indian medical philanthropy as also leukaemia and cancer research.